In an era where clinical practice is increasingly dominated by imaging, algorithms, and automated diagnostics, the ability to recognize, interpret, and defend physical signs remains one of the most essential yet endangered skills in medicine and neurology. Volume 3 (R–Z) of the Dictionary of Eponymous Physical Signs and Markers responds to this growing gap by presenting more than 400 classical and modern diagnostic entries, from Raccoon Eyes to Ziehen-Oppenheim Sign, integrating historical development, clinical application, and medico-legal relevance within a single authoritative reference. Rather than functioning as a simple listing of terms, this volume serves as a practical diagnostic, academic, and forensic resource, recognizing that bedside signs continue to shape early diagnosis, surgical decision-making, expert testimony, and professional accountability. Designed for neurologists, neurosurgeons, physicians, surgeons, forensic specialists, postgraduate students, researchers, institutional libraries, and pharmaceutical and medtech organizations, it bridges neurology, medicine, and surgery through structured entries that trace discovery, pathophysiology, clinical impact, and legal significance. By completing this trilogy in a 456-page, large-format atlas, the volume preserves the central role of clinical examination in modern healthcare, ensuring that practitioners remain equipped to translate observation into accurate diagnosis, defensible judgment, and reliable evidence in both hospitals and courtrooms worldwide.